The p53 antibody (DO-1) is a high-quality monoclonal antibody (also called the tumor suppressor protein as p53, or TP53 antibody) which is suitable for the identification that the protein p53 is that is of a mouse or rat origin, as well as human. You can know more about the p53 antibodies via www.bosterbio.com/anti-p-glycoprotein-antibody-rp1034-boster.html.
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The p53 Antibody (DO-1) is available in both the unconjugated anti-p53 antibody version and also different conjugated versions of the anti-p53 antibody. These include HRP, agarose, PE, FITC, and multiple Alexa Fluor(r) conjugates.
It is known as a DNA binding, the oligomerization domain as well as transcription activation domain-containing cancer suppressor.
The p53 protein increases the expression of the genes involved in apoptosis and growth arrest as a response to signals of stress, inducing programmed cell death cell differentiation, as well as cells' cycle-control mechanisms.
The p53 Antibody is able to stain the cytoplasm and nucleus since the p53 protein is located in the nucleus, but it can be chaperoned into the cytoplasm via MDM2, the regulator that is negative.
MDM2 can be described as an E3 Ubiquitin Ligase that is elevated when it is in contact with active p53. It can poly-ubiquitinated p53 for proteasome-targeting.
P53 varies between active and latent DNA binding conformations and is activated by posttranslational modifications such as acetylation and phosphorylation. P53 Antibody, therefore, is an important reagent in cancer research.